What is Erlotinib hydrochloride?

Posted: November 6, 2013 in Medicine raw material
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CAS:183319-69-9

Molecular formula:C22H23N3O4.HCl

Molecular weight:429.9

Appearance: Off-white to pale yellow powder

Solubility: Soluble in DMSO at 18 mg/mL with warming; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 5-20 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility.

Storage: Store at -20° C

Application: An HER-1/EGFR tyrosine kinase inhibitor

Usage:

drug used to treat non-small cell lung cancer, pancreatic cancer and several other types of cancer. It is a tyrosine kinase inhibitor, which acts on the epidermal growth factor receptor

Product description:Erlotinib hydrochloride is an HER-1/EGFR tyrosine kinase inhibitora, a small molecule inhibitor of the human epidermal growth factor receptor (HER-1/EGFR) tyrosine kinase. Overexpression of the EGFR is present in many carcinomas, and inhibition of the activating kinase by Erlotinib provides a chemical intervention upon these systems.

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