What is Eldecalcitol?

Posted: November 22, 2013 in Medicine raw material

Eldecalcitol [1α,25-dihydroxy-2β-(3-hydroxypropyloxy)-vitamin D₃] is an alternation of 1α,25-dihydroxyvitamin D₃ [1,25(OH)₂D₃], address a hydroxypropyloxy balance at the 2β position. Eldecalcitol shows stronger furnishings than alfacalcidol to access cartilage mineral body and abate cartilage absorption markers in osteoporotic patients, and articulate once-daily 0.75 μg eldecalcitol bargain vertebral breach accident by 26% compared to 1.0 μg alfacalcidol in a 3-year randomized, double-blind, active-comparator analytic trial. The aftereffect of eldecalcitol on vertebral breach accident was abiding throughout the 3-year abstraction period, and the anniversary accident of vertebral breach during the third year was decidedly lower with eldecalcitol rather than with alfacalcidol analysis (3.9% vs 7.0%, respectively). Eldecalcitol aswell bargain the accident of wrist fractures by 71% compared to alfacalcidol. Eldecalcitol is able-bodied acceptable and is not associated with austere ancillary furnishings including abiding hypercalcemia. Eldecalcitol was accustomed for the analysis of osteoporosis in Japan in 2011.


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