Insulin-like growth factor-binding protein 4 Introduction

Posted: August 8, 2014 in Elisa assay kits

Insulin-like growth factor-binding protein 4 is a protein that in bodies is encoded by the IGFBP4 gene.

This gene is a affiliate of the insulin-like growth factor binding protein (IGFBP) ancestors and encodes a protein with an IGFBP area and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the claret in both glycosylated and non-glycosylated forms. Bounden of this protein prolongs the half-life of the IGFs and alters their alternation with corpuscle apparent receptors. IGFBP-4 is a different protein and it consistently inhibits several blight beef in vivo and in vitro. Its inhibitory activity has been apparent in vivo in prostate and colon. It is buried by all colon blight cells.

The protein itself does not anticipate the accumulation of cancer. However it may abate the advance of blight and act as an apoptotic factor.


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