What is Chloramphenicol?

Posted: June 4, 2016 in Uncategorized
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Chloramphenicol is a broad-spectrum antibacterial that was acquired from the bacillus Streptomyces venezuelae and is now produced synthetically. Chloramphenicol is able adjoin a advanced array of microorganisms, but due to austere side-effects (e.g., accident to the cartilage marrow, including aplastic anemia) in humans, it is usually aloof for the analysis of austere and life-threatening infections (e.g., typhoid fever). Chloramphenicol is bacteriostatic but may be antibacterial in top concentrations or if acclimated adjoin awful affected organisms. Chloramphenicol stops bacterial advance by bounden to the bacterial ribosome (blocking peptidyl transferase) and inhibiting protein synthesis.

Chloramphenicol is lipid-soluble, acceptance it to broadcast through the bacterial corpuscle membrane. It again reversibly binds to the L16 protein of the 50S subunit of bacterial ribosomes, area alteration of amino acids to growing peptide chains is prevented (perhaps by abolishment of peptidyl transferase activity), appropriately inhibiting peptide band accumulation and consecutive protein synthesis.

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