Pyrrolidine Synthesis and Occurrence

Posted: September 10, 2016 in Medicine raw material

Pyrrolidine is a achromatic to anemic chicken aqueous with an ammonia-like odor. Vapors added than air. Produces baneful oxides of nitrogen during combustion.Pyrrolidine, aswell accepted as tetrahydropyrrole, is an amoebic admixture with the atomic blueprint (CH2)4NH. It is a circadian accessory amine, aswell classified as a saturated heterocycle. It is a colourless aqueous that is miscible with baptize and a lot of amoebic solvents. It has a appropriate semen-like odor.Compared to acyclic accessory amines, it is about 10 times added basic.

Pyrrolidine is produced industrially by analysis of 1,4-butanediol with ammonia over an oxide catalyst.

Pyrrolidine is begin in the leaves of tobacco and carrot. The pyrrolidine ring anatomy is present in abundant accustomed alkaloids such as nicotine and hygrine. It is begin in abounding biologic drugs such as procyclidine and bepridil. It aswell forms the base for the racetam compounds. The amino acids proline and hydroxyproline are, in a structural sense, derivatives of pyrrolidine.


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