What is Perifosine?

Posted: May 6, 2017 in Medicine raw material

CAS: 157716-52-4
Molecular Formula: C25H52NO4P
Molecular weight:461.65848
Perifosine is an alkylphospholipid (octadecyl-(1,1-dimethyl-4-piperidylio) phosphate) which inhibits Akt activation. Perifosine has been advised for abeyant analysis of a advanced array of cancers. Targeting cellular membranes, Perifosine modulates film permeability, film lipid composition, phospholipid metabolism, and mitogenic arresting transduction, consistent in corpuscle adverse and inhibition of corpuscle growth. Perifosine aswell inhibits the anti-apoptotic mitogen-activated protein kinase (MAPK) alleyway and modulates the antithesis amid the MAPK and pro-apoptotic stress-activated protein kinase (SAPK/JNK) pathways, thereby inducing apoptosis. Perifosine has a lower gastrointestinal toxicity contour than the accompanying abettor Miltefosine.


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