Structural basis for kasugamycin action

Posted: May 28, 2017 in Medicine raw material

The X-ray anatomy of kasugamycin in circuitous with the Escherichia coli 70S ribosome has been bent at 3.5-A resolution. The anatomy reveals that the biologic binds aural the agent RNA approach of the 30S subunit amid the universally conserved G926 and A794 nucleotides in 16S ribosomal RNA, which are sites of kasugamycin resistance.
The kasugamycin bounden sites are present on top of braid 44 (h44), spanning the arena amid h24 and h28, which contacts the conserved nucleotides A794 and G926. Neither bounden position overlaps with P-site tRNA. Instead, kasugamycin mimics the codon nucleotides at the P and E sites by bounden aural the aisle of the mRNA, appropriately annoying the mRNA-tRNA codon-anticodon interaction.


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