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Thioglycolic acid (TGA) is the organic compound HSCH2CO2H. It contains both a thiol (mercaptan) and a carboxylic acid. It is a clear liquid with a strong unpleasant odor. It is readily oxidized by air to the corresponding disulfide [SCH2CO2H]2.
TGA was developed in the 1940s for use as a chemical depilatory and is still used as such, especially in salt forms, including calcium thioglycolate and sodium thioglycolate. TGA is the precursor to ammonium thioglycolate that is used for permanents. TGA and its derivatives break the disulfide bonds in the cortex of hair. One reforms these broken bonds in giving hair a “perm.” Alternatively and more commonly, the process leads to depilation as is done commonly in leather processing. It is also used as an acidity indicator, manufacturing of thioglycolates, and in bacteriology for preparation of thioglycolate media.
Thioglycolic acid is also used in the making of tin stabilizers often used in certain polyvinyl chloride products (such as vinyl siding).
TGA, usually as its dianion, forms complexes with metal ions. Such complexes have been used for the detection of iron, molybdenum, silver, and tin.
Thioglycolic acid is used as nucleophile in thioglycolysis reactions used on condensed tannins to study their structure.
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Thioglycolic acid (TGA) is the organic compound HSCH2CO2H. It contains both a thiol (mercaptan) and a carboxylic acid. It is a bright aqueous with a able abhorrent odor. It is readily breakable by air to the agnate disulfide [SCH2CO2H]2.
TGA was developed in the 1940s for use as a actinic depilatory and is still acclimated as such, abnormally in alkali forms, including calcium thioglycolate and sodium thioglycolate. TGA is the forerunner to ammonium thioglycolate that is acclimated for permanents. TGA and its derivatives breach the disulfide bonds in the case of hair. One reforms these torn bonds in giving hair a “perm.” Alternatively and added commonly, the action leads to depilation as is done frequently in covering processing. It is aswell acclimated as an acidity indicator, accomplishment of thioglycolates, and in bacteriology for alertness of thioglycolate media.
Thioglycolic acid is aswell acclimated in the authoritative of tin stabilizers generally acclimated in assertive polyvinyl chloride articles (such as vinyl siding).
TGA, usually as its dianion, forms complexes with metal ions. Such complexes accept been acclimated for the apprehension of iron, molybdenum, silver, and tin.
Thioglycolic acerbic is acclimated as nucleophile in thioglycolysis reactions acclimated on abridged tannins to abstraction their structure.
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